Maria A. Fiatarone, Evelyn F. O'Neill, Nancy Doyle
Ryan, Karen M. Clements, Guido R. Solares, Miriam E. Nelson, Susan B.
Roberts, Joseph J. Kehayias, Lewis A. Lipsitz, and William J. Evans
N Engl J Med 1994; 330:1769-1775June 23, 1994DOI: 10.1056/NEJM199406233302501
Exercise Training and Nutritional Supplementation for Physical Frailty in Very Elderly People
The decline in muscle strength and mass during aging
1,2 has been linked to physical frailty, falls, functional decline, and impaired mobility in very elderly people
3-5.
Although many factors, including chronic illness, a sedentary
lifestyle, nutritional deficiencies, and aging itself, may contribute to
muscle weakness and loss of skeletal-muscle mass in people of advanced
age,
6-10 currently only skeletal-muscle disuse
11,12 and undernutrition
13-15 are potentially preventable or reversible with targeted interventions.
Muscle dysfunction associated with malnutrition may improve with nutritional supplementation in younger patients
16,17.
Even in healthy elderly men, a multinutrient supplement augmented
muscle hypertrophy, although not muscle strength, during a resistance
training regimen similar to the one described here
18.
We
hypothesized that physical frailty is partially mediated by
skeletal-muscle disuse and marginal nutritional intake, and should
therefore be reduced by interventions designed to reverse these
deficits.
Methods
Study Design
Detailed
descriptions of the rationale and design of the Boston FICSIT (Frailty
and Injuries: Cooperative Studies of Intervention Techniques) study
19 and the entire FICSIT trial
20
have been published elsewhere. Briefly, the Boston FICSIT study was a
randomized, placebo-controlled, 10-week clinical trial in which the
subjects were assigned to receive lower-extremity resistance training, a
multinutrient supplement, both treatments, or a placebo activity and
supplement. The study was approved by the human investigations review
committees at New England Medical Center and the Hebrew Rehabilitation
Center for Aged, and written informed consent was obtained from each
subject.
Study Population
Volunteers
were recruited from the residents of a 725-bed facility providing
long-term care of the elderly. The criteria for inclusion were
residential status, an age over 70 years, and the ability to walk 6 m.
Subjects were excluded if they had severe cognitive impairment, rapidly
progressive or terminal illness, acute illness or unstable chronic
illness, myocardial infarction, fracture of a lower extremity within the
six months before the study, or insulin-dependent diabetes mellitus; if
they were on a weight-loss diet or undergoing resistance training at
the time of enrollment; or if tests of muscle strength revealed a
musculoskeletal or cardiovascular abnormality.
Interventions
Resistance Training
Subjects assigned to exercise training underwent a regimen of high-intensity progressive resistance training
21
of the hip and knee extensors 3 days per week for 10 weeks. These
muscle groups were chosen because of their importance in functional
activities
22.
For each muscle group, the resistance was set at 80 percent of the
one-repetition maximum (the maximal load that could be lifted fully one
time only)
23.
To maintain the intensity of the stimulus, the load was increased at
each training session, as tolerated by the subject. Strength testing was
repeated every two weeks to establish a new base-line value.
Training
sessions lasted 45 minutes and were separated by one day of rest. Each
repetition lasted six to nine seconds, with a one- to two-second rest
between repetitions and a two-minute rest between the three sets of
eight lifts. All exercise sessions were supervised individually by a
single exercise trainer, who was a certified therapeutic recreation
specialist.
The knee extensors were trained with the use of the
UNEX II chair (J.A. Preston, Clifton, N.J.). The hip extensors were
trained in the first 53 subjects with the use of a wall-mounted
cable-pulley system (G.E. Miller, New York). In the other 47 subjects, a
double leg press (Keiser Sports Health Equipment, Fresno, Calif.) was
used in place of the cable-pulley system, since it allowed for better
positioning of the subject. There were no differences at base line or in
treatment outcomes between subjects trained on these two machines............
Quelle: Abstract und Full Text:
http://www.nejm.org/doi/full/10.1056/NEJM199406233302501#t=article
Full Text / pdf / online im internet / Zugriff vom 04.10.2012 -
Exercise Training and Nutritional Supplementation for Physical Frailty in Very Elderly People :
http://web.missouri.edu/~brownmb/pt415/Mb/2007/articles/4.Fiatarone1994.pdf
Mauerbergstraße 110
76534 Baden-Baden
Tel.: 07223 / 8004699
Mobil: 0177 / 4977232
Mail: info@aktiv-training.de
Fax: 07223 / 8005271
Training: www.training-baden-baden.de
Gesundheitsmanager: www.gesundheitsmanager-24.de