Donnerstag, 4. Oktober 2012

Development of a Common Outcome Data Set for Fall Injury Prevention Trials

The Prevention of Falls Network Europe Consensus



Keywords:

  • accidental falls;
  • aged;
  • fractures;
  • consensus development;
  • outcome measures
The prevention of injury associated with falls in older people is a public health target in many countries around the world. Although there is good evidence that interventions such as multifactorial fall prevention and individually prescribed exercise are effective in reducing falls, the effect on serious injury rates is unclear.1,2 Historically, trials have not been adequately powered to detect injury endpoints, and variations in case definition across trials have hindered meta-analysis.1

It is possible that fall-prevention strategies have limited effect on falls that result in injuries or are ineffective in populations who are at a higher risk of injury.

Further research is required to determine whether fall-prevention interventions can reduce serious injuries.
Prevention of Falls Network Europe (ProFaNE) is a collaborative project to reduce the burden of fall injury in older people through excellence in research and promotion of best practice (http://www.profane.eu.org). The European Commission funds the network, which links clinicians, members of the public, and researchers worldwide.

The aims are to identify major gaps in knowledge in fall injury prevention and to facilitate the collaboration necessary for large-scale clinical research activity, including clinical trials, comparative research, and prospective meta-analysis.

Work is being undertaken in a 4-year program. As a first step, the development of a common set of outcome definitions and measures for future trials or meta-analysis was considered.

Quelle:  http://onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.2005.53455.x/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=true



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Exercise Training and Nutritional Supplementation for Physical Frailty in Very Elderly People

Maria A. Fiatarone, Evelyn F. O'Neill, Nancy Doyle Ryan, Karen M. Clements, Guido R. Solares, Miriam E. Nelson, Susan B. Roberts, Joseph J. Kehayias, Lewis A. Lipsitz, and William J. Evans
N Engl J Med 1994; 330:1769-1775June 23, 1994DOI: 10.1056/NEJM199406233302501

Exercise Training and Nutritional Supplementation for Physical Frailty in Very Elderly People


The decline in muscle strength and mass during aging1,2 has been linked to physical frailty, falls, functional decline, and impaired mobility in very elderly people3-5.

Although many factors, including chronic illness, a sedentary lifestyle, nutritional deficiencies, and aging itself, may contribute to muscle weakness and loss of skeletal-muscle mass in people of advanced age,6-10 currently only skeletal-muscle disuse11,12 and undernutrition13-15 are potentially preventable or reversible with targeted interventions.

Muscle dysfunction associated with malnutrition may improve with nutritional supplementation in younger patients16,17. Even in healthy elderly men, a multinutrient supplement augmented muscle hypertrophy, although not muscle strength, during a resistance training regimen similar to the one described here18.

We hypothesized that physical frailty is partially mediated by skeletal-muscle disuse and marginal nutritional intake, and should therefore be reduced by interventions designed to reverse these deficits.

Methods

Study Design

Detailed descriptions of the rationale and design of the Boston FICSIT (Frailty and Injuries: Cooperative Studies of Intervention Techniques) study19 and the entire FICSIT trial20 have been published elsewhere. Briefly, the Boston FICSIT study was a randomized, placebo-controlled, 10-week clinical trial in which the subjects were assigned to receive lower-extremity resistance training, a multinutrient supplement, both treatments, or a placebo activity and supplement. The study was approved by the human investigations review committees at New England Medical Center and the Hebrew Rehabilitation Center for Aged, and written informed consent was obtained from each subject.

Study Population

Volunteers were recruited from the residents of a 725-bed facility providing long-term care of the elderly. The criteria for inclusion were residential status, an age over 70 years, and the ability to walk 6 m. Subjects were excluded if they had severe cognitive impairment, rapidly progressive or terminal illness, acute illness or unstable chronic illness, myocardial infarction, fracture of a lower extremity within the six months before the study, or insulin-dependent diabetes mellitus; if they were on a weight-loss diet or undergoing resistance training at the time of enrollment; or if tests of muscle strength revealed a musculoskeletal or cardiovascular abnormality.

Interventions

Resistance Training

Subjects assigned to exercise training underwent a regimen of high-intensity progressive resistance training21 of the hip and knee extensors 3 days per week for 10 weeks. These muscle groups were chosen because of their importance in functional activities22. For each muscle group, the resistance was set at 80 percent of the one-repetition maximum (the maximal load that could be lifted fully one time only)23. To maintain the intensity of the stimulus, the load was increased at each training session, as tolerated by the subject. Strength testing was repeated every two weeks to establish a new base-line value.
Training sessions lasted 45 minutes and were separated by one day of rest. Each repetition lasted six to nine seconds, with a one- to two-second rest between repetitions and a two-minute rest between the three sets of eight lifts. All exercise sessions were supervised individually by a single exercise trainer, who was a certified therapeutic recreation specialist.
The knee extensors were trained with the use of the UNEX II chair (J.A. Preston, Clifton, N.J.). The hip extensors were trained in the first 53 subjects with the use of a wall-mounted cable-pulley system (G.E. Miller, New York). In the other 47 subjects, a double leg press (Keiser Sports Health Equipment, Fresno, Calif.) was used in place of the cable-pulley system, since it allowed for better positioning of the subject. There were no differences at base line or in treatment outcomes between subjects trained on these two machines............

Quelle:  Abstract und Full Text:
http://www.nejm.org/doi/full/10.1056/NEJM199406233302501#t=article
 

Full Text / pdf / online im internet / Zugriff vom 04.10.2012 -

Exercise Training and Nutritional Supplementation for Physical Frailty in Very Elderly People :


http://web.missouri.edu/~brownmb/pt415/Mb/2007/articles/4.Fiatarone1994.pdf





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Factors Predicting Dynamic Balance and Quality of Life in Home-Dwelling Elderly Women

Abstract:

Background:

Proper balance seems to be a critical factor in terms of fall prevention among the elderly. Objective: The purpose of this cross-sectional study was to examine factors that are associated with dynamic balance and health-related quality of life in home-dwelling elderly women.  

Methods:

One hundred and fifty-three healthy postmenopausal women (mean age: 72 years, height: 159 cm, weight: 72 kg) were examined. General health and physical activity were assessed by a questionnaire. Quality of life was measured using a health-related quality of life questionnaire (Rand 36-Item Health Survey 1.0). Dynamic balance (agility) was tested by a figure-of-eight running test. Static balance (postural sway) was tested on an unstable platform. Maximal isometric strength of the leg extensors was measured with a leg press dynamometer. Dynamic muscle strength of lower limbs was tested by measuring ground reaction forces with a force platform during common daily activities (sit-to-stand and step-on-a-stair tests).  

Results:

Concerning physical activity, 33% of the subjects reported brisk exercise (walking, Nordic walking, cross-country skiing, swimming and aquatic exercises) at least twice a week, and 22% some kind of brisk activity once a week in addition to lighter physical exercise. The remaining 45% did not exercise regularly and were classified as sedentary. The correlations of step-on-a-stair and sit-to-stand ground reaction forces, and leg extensor strength to dynamic balance were from –0.32 to –0.43 (the better the strength, the better the balance). In the regression analysis with backward elimination, step-on-a-stair and sit-to-stand ground reaction forces, and leg extensor strength, age, brisk physical activity, number of diseases and dynamic postural stability explained 42% of the variance in the dynamic balance. Similarly, dynamic balance (figure-of-eight running time), number of diseases and walking more than 3 km per day explained 14% of the variance in the quality of life score. Of these, figure-of-eight running time was the strongest predictor of the quality of life score, explaining 9% of its variance.  

Conclusion:

This study emphasizes the concept that in home-dwelling elderly women good muscle strength in lower limbs is crucial for proper body balance and that dynamic balance is an independent predictor of a standardized quality of life estimate. The results provide important and useful information when planning meaningful contents for studies related to fall prevention and quality of life and interventions in elderly women.

Quelle:  http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstractBuch&ArtikelNr=82196&ProduktNr=230593






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Implementation of multifactorial interventions for fall and fracture prevention

  1. M. Clare Robertson

Abstract

Over 60% of falls experienced by older people result from multiple aetiological factors. Preventing falls in individual patients requires the identification and treatment of these interacting factors. Multifactorial interventions have been successful in some, but not all, fall prevention trials. Preventing falls in populations requires selection of the population most likely to benefit, and selection of the particular interventions shown to have been effective in this group. The implementation of preventive measures has been low despite strong evidence that fall and fractures can be reduced. Misconceptions about the potential for prevention in old age, the time to effect improvement, resource issues and the nature of the interventions contribute to the low uptake. An improved system of delivery of proven preventive measures is needed.

Key words:


Quelle:  http://ageing.oxfordjournals.org/content/35/suppl_2/ii60.short



Full Text / Link / online im internet / Zugriff vom 04.10.2012:  

Implementation of multifactorial interventions for fall and fracture prevention  - Autoren: 
  1. M. Clare Robertson

http://ageing.oxfordjournals.org/content/35/suppl_2/ii60.full.pdf+html



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Mittwoch, 3. Oktober 2012

Balance training program is highly effective

Balance training program is highly effective in improving functional status and reducing the risk of falls in elderly women with osteoporosis: a randomized controlled trial
Direktlink / Full Text / pdf - online im internet - Zugriff vom 03.10.2012:

http://www.biomedsearch.com/attachments/00/17/08/90/17089080/198_2006_Article_252.pdf





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Systematic Review of Progressive Resistance Strength Training in Older Adults


Abstract

Background. The aim of this systematic review was to quantify the effectiveness of progressive resistance strength training (PRT) to reduce physical disability in older people. 

Methods. Randomized controlled trials were identified from searches of relevant databases and study reference lists and contacts with researchers. Two reviewers independently screened the trials for eligibility, rated their quality, and extracted data. Only randomized controlled trials utilizing PRT as the primary intervention in participants, whose group mean age was 60 years or older, were included. Data were pooled using fixed or random effect models to produce weighted mean differences (WMD) and 95% confidence intervals (CI). Standardized mean differences (SMD) were calculated when different units of measurement were used for the outcome of interest.

Results. 62 trials (n = 3674) compared PRT with a control group. 14 trials had data available to allow pooling of disability outcomes. Most trials were of poor quality. PRT showed a strong positive effect on strength, although there was significant heterogeneity (41 trials [n = 1955], SMD 0.68; 95% confidence interval [CI] 0.52, 0.84). A modest effect was found on some measures of functional limitations such as gait speed (14 trials [n = 798], WMD 0.07 meters per second; 95% CI 0.04, 0.09). No evidence of an effect was found for physical disability (10 trials [n = 722], SMD 0.01; 95% CI −0.14, 0.16). Adverse events were poorly investigated, but occurred in most studies where they were defined and prospectively monitored.

Conclusions. PRT results in improvements to muscle strength and some aspects of functional limitation, such as gait speed, in older adults. However, based on current data, the effect of PRT on physical disability remains unclear. Further, due to the poor reporting of adverse events in trials, it is difficult to evaluate the risks associated with PRT.


Quelle:   http://biomedgerontology.oxfordjournals.org/content/59/1/M48.short



Hier der Download-Link zu:    Systematic Review of Progressive Resistance Strength Reistance Strength Training in Older Adults:


http://www.bewegenismedicijn.nl/files/downloads/latham_et_al._2004_-_prt_in_older_adults.pdf





Hier der Link zum Cochrane-Review von LIU und LATHAM - 2009:

"Progressive Resistance Strength Training for improving physical function in older adults"  (277 Seiten)

http://www.cfah.org/hbns/archives/viewSupportDoc.cfm?supportingDocID=806




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Falls in the nursing home

ABSTRACT  von 1994


OBJECTIVE:

To review the epidemiology and causes of falls and fall-related injuries in nursing homes and to provide clinicians with a structured framework to evaluate and treat nursing home residents at risk for falls.

DATA SOURCES:

All large-scale published studies documenting incidence, causes, risk factors, and preventive strategies for falls in nursing homes were reviewed.

RESULTS:

The mean incidence of falls in nursing homes is 1.5 falls per bed per year (range, 0.2 to 3.6 falls). The most common precipitating causes include gait and balance disorders, weakness, dizziness, environmental hazards, confusion, visual impairment, and postural hypotension. The most important underlying risk factors for falls and injuries include some of these same items and others, such as lower-extremity weakness, gait and balance instability, poor vision, cognitive and functional impairment, and sedating and psychoactive medications. Many strategies for the prevention of falls have been tried, with mixed success. The most successful consider the multifactorial causes of falls and include interventions to improve strength and functional status, reduce environmental hazards, and allow staff to identify and monitor high-risk residents. Strategies that reduce mobility through use of restraints have been shown to be more harmful than beneficial and should be avoided.

CONCLUSIONS:

A focused history and physical examination after a fall can usually determine both the immediate underlying causes of the fall and contributing risk factors. In addition, regular evaluations in the nursing home can help identify patients at high risk who can then be targeted for specific treatment and prevention strategies.

Quelle:   http://www.ncbi.nlm.nih.gov/pubmed/8053619



Full Text / pdf / RUBENSTEIN et al. - Falls in the nursing home - http://mcintranet.musc.edu/agingq3/documents/images/Rubenstein_Falls%20in%20the%20Nursing%20Home.pdf



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Effectiveness of a Multifaceted Intervention on Falls

Abstract:  Effectiveness of a Multifaceted Intervention on Falls in Nursing Home Residents  - Clemens Becker et al -
Article first published online: 20 FEB 2003
DOI: 10.1046/j.1532-5415.2003.51103.x

ABSTRACT 

Keywords:

  • accidental falls;
  • older people;
  • prevention;
  • hip protector;
  • exercise
OBJECTIVES:   To evaluate the effectiveness of a multifaceted, nonpharmaceutical intervention on incidence of falls and fallers.
DESIGN:   Prospective, cluster-randomized, controlled 12-month trial.
SETTING:   Six community nursing homes in Germany.
PARTICIPANTS:   Long-stay residents (n = 981) aged 60 and older; mean age 85; 79% female.
INTERVENTIONS:   Staff and resident education on fall prevention, advice on environmental adaptations, progressive balance and resistance training, and hip protectors.
MEASUREMENTS:   Falls, fallers, and fractures.
RESULTS:   The incidence density rate of falls per 1,000 resident years (RY) was 2,558 for the control group (CG) and 1,399 for the intervention group (IG) (relative risk (RR) = 0.55, 95% confidence interval (CI) = 0.41–0.73). Two hundred forty-seven (52.3%) fallers were detected in the CG and 188 (36.9%) in the IG (RR = 0.75, 95% CI = 0.57–0.98). The incidence density rate of frequent fallers (>2/year) was 115 (24.4%) for the CG and 66 (13.0%) for the IG (RR = 0.56, 95% CI = 0.35–0.89). The incidence density rate of hip fractures per 1,000 RY was 39 for the CG and 43 for the IG (RR = 1.11, 95% CI = 0.49–2.51). Other fractures were diagnosed with an incidence density rate of 52 per 1,000 RY for CG and 41 per 1,000 RY for IG (RR = 0.78, 95% CI = 0.57–1.07).
CONCLUSION:   The incidence density rate of falls and fallers differed considerably between the control and intervention groups. The study was underpowered to demonstrate a significant difference of hip or nonhip fractures. Because of a low fracture rate in both groups, the investigation of fracture rates would have required a larger sample size to detect an effect of the intervention.

Quelle: http://onlinelibrary.wiley.com/doi/10.1046/j.1532-5415.2003.51103.x/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=true




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Intense Tai Chi Exercise Training and Fall Occurrences

 Abstract:  Intense Tai Chi Exercise Training and Fall Occurrences in Older, Transitionally Frail Adults: A Randomized, Controlled Trial

 Keywords:

  • exercise;
  • falls;
  • balance;
  • aging;
  • tai chi
Objectives: To determine whether an intense tai chi (TC) exercise program could reduce the risk of falls more than a wellness education (WE) program in older adults meeting criteria for transitioning to frailty.
Design: Randomized, controlled trial of 48 weeks duration.
Setting: Twenty congregate living facilities in the greater Atlanta area.
Participants: Sample of 291 women and 20 men aged 70 to 97.
Measurements: Demographics, time to first fall and all subsequent falls, functional measures, Sickness Impact Profile, Centers for Epidemiologic Studies—Depression Scale, Activities-specific Balance Confidence Scale, Falls Efficacy Scales, and adherence to interventions.
Results: The risk ratio (RR) of falling was not statistically different in the TC group and the WE group (RR=0.75, 95% confidence interval (CI)=0.52–1.08), P=.13). Over the 48 weeks of intervention, 46% (n=132) of the participants did not fall; the percentage of participants that fell at least once was 47.6% for the TC group and 60.3% for the WE group.
Conclusion: TC did not reduce the RR of falling in transitionally frail, older adults, but the direction of effect observed in this study, together with positive findings seen previously in more-robust older adults, suggests that TC may be clinically important and should be evaluated further in this high-risk population.

Quelle:  http://onlinelibrary.wiley.com/doi/10.1046/j.1532-5415.2003.51552.x/abstract




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Montag, 1. Oktober 2012

The Effect of Multidimensional Exercises .....

....... on Balance, Mobility, and Fall Risk in Community-Dwelling Older Adults

Abstract

Background and Purpose. 
This prospective clinical investigation examined the effects of a multidimensional exercise program on balance, mobility, and risk for falls in community-dwelling older adults with a history of falling. Factors used to predict adherence and a successful response to exercise were identified. 

Subjects. A total of 105 community-dwelling older adults (≥65 years of age) with a history of two or more falls in the previous 6 months (no neurologic diagnosis) participated. They were classified into (1) a control group of fallers (n=21), (2) a fully adherent exercise group (n=52), and (3) a partially adherent exercise group (n=32). 

Methods. Following evaluation, each patient received an individualized exercise program addressing the impairments and functional disabilities identified during the assessment. The control group received no intervention. Changes in performance on five clinical tests of balance and mobility and fall risk were compared among groups.  

Results. Both exercise groups scored better than the control group on all measures of balance and mobility. Although both exercise groups showed a reduction in fall risk compared with the control group, the greatest reduction was found in the fully adherent exercise group. Factors associated with successful response to exercise included degree of adherence to exercise program and pretest score on the Tinetti Mobility Assessment.  

Conclusion and Discussion. Exercise can improve balance and mobility function and reduce the likelihood for falls among community-dwelling older adults with a history of falling. The amount of exercise needed to achieve these results, however, could not be determined from this study.


Quelle:  http://www.physicaltherapyjournal.com/content/77/1/46.short


Full Text / pdf - online im internet - Zugriff 01.10.2012 -  The Effect of Multidimensional Exercises on Balance, Mobility, and Fall Risk in Community-Dwelling Older Adults

http://www.physicaltherapyjournal.com/content/77/1/46.full.pdf+html





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Interventions for the prevention of falls in older adults

A systematic review and meta-analysis of randomised clinical trials - 

Autoren: 

John T Chang, clinical instructor,1 Sally C Morton, codirector,2 Laurence Z Rubenstein, professor,3 Walter A Mojica, physician reviewer,2 Margaret Maglione, policy analyst,2 Marika J Suttorp, quantitative analyst,2 Elizabeth A Roth, senior programmer analyst,2 and Paul G Shekelle, professor1


Abstract

Objective To assess the relative effectiveness of interventions to prevent falls in older adults to either a usual care group or control group.

Design Systematic review and meta-analyses.

Data sources Medline, HealthSTAR, Embase, the Cochrane Library, other health related databases, and the reference lists from review articles and systematic reviews.

Data extraction Components of falls intervention: multifactorial falls risk assessment with management programme, exercise, environmental modifications, or education.

Results 40 trials were identified. A random effects analysis combining trials with risk ratio data showed a reduction in the risk of falling (risk ratio 0.88, 95% confidence interval 0.82 to 0.95), whereas combining trials with incidence rate data showed a reduction in the monthly rate of falling (incidence rate ratio 0.80, 0.72 to 0.88). The effect of individual components was assessed by meta-regression. A multifactorial falls risk assessment and management programme was the most effective component on risk of falling (0.82, 0.72 to 0.94, number needed to treat 11) and monthly fall rate (0.63, 0.49 to 0.83; 11.8 fewer falls in treatment group per 100 patients per month). Exercise interventions also had a beneficial effect on the risk of falling (0.86, 0.75 to 0.99, number needed to treat 16) and monthly fall rate (0.86, 0.73 to 1.01; 2.7).

Conclusions Interventions to prevent falls in older adults are effective in reducing both the risk of falling and the monthly rate of falling. The most effective intervention was a multifactorial falls risk assessment and management programme. Exercise programmes were also effective in reducing the risk of falling.




 Full Text / pdf - online im internet - Zugriff: 01.10.2012 -   Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials

http://mcintranet.musc.edu/agingq3/documents/images/Chang_Interventions%20for%20the%20Prevention%20of%20Falls.pdf






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Effects of a Group Exercise Program on Strength, Mobility, and Falls

Among Fall-Prone Elderly Men  / by:


  1. Alan S. Robbins

Abstract

Objectives. This randomized controlled trial studied the effects of a low- to moderate-intensity group exercise program on strength, endurance, mobility, and fall rates in fall-prone elderly men with chronic impairments. 

Methods. Fifty-nine community-living men Formula with specific fall risk factors (i.e., leg weakness, impaired gait or balance, previous falls) were randomly assigned to a control group Formula or to a 12-week group exercise program Formula. Exercise sessions (90 minutes, three times per week) focused on increasing strength and endurance and improving mobility and balance. Outcome measures included isokinetic strength and endurance, five physical performance measures, and self-reported physical functioning, health perception, activity level, and falls. 

Results. Exercisers showed significant improvement in measures of endurance and gait. Isokinetic endurance increased 21% for right knee flexion and 26% for extension. Exercisers had a 10% increase ( p < .05) in distance walked in six minutes, and improved ( p < .05) scores on an observational gait scale. Isokinetic strength improved only for right knee flexion. Exercise achieved no significant effect on hip or ankle strength, balance, self-reported physical functioning, or number of falls. Activity level increased within the exercise group. When fall rates were adjusted for activity level, the exercisers had a lower 3-month fall rate than controls (6 falls/1000 hours of activity vs 16.2 falls/1000 hours, p < .05). 

Discussion. These findings suggest that exercise can improve endurance, strength, gait, and function in chronically impaired, fall-prone elderly persons. In addition, increased physical activity was associated with reduced fall rates when adjusted for level of activity. 



Full Text / pdf - online im internet - Zugriff 01.10.12

http://web.missouri.edu/~brownmb/pt415/Mb/2008/Rubenstein-2000-mobilitiy-and-fall-rate_J_Gerontol_A-FULL.pdf






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Practical implementation of an exercise‐based falls prevention programme


Abstract

Muscle weakness and impaired balance are risk factors underlying many falls and fall injuries experienced by older people. Fall prevention strategies have included exercise programmes that lower the risk of falling by improving strength and balance. We have developed an individually tailored, home‐based, strength and balance retraining programme, which has proven successful in reducing falls and moderate fall injuries in people aged 80 years and older. Here we describe a simple assessment of strength and balance and the content and delivery of a falls prevention exercise programme.

Key words:exercise; falls; older people


Quelle:  http://ageing.oxfordjournals.org/content/30/1/77.short



Online im internet - Zugriff 01.10.2012 -

Practical implementation of an exercise‐based falls prevention programme -

Full Text / pdf:  http://ageing.oxfordjournals.org/content/30/1/77.full.pdf+html







JÖRG LINDER AKTIV-TRAINING – Ihr Personal Trainer für Sturzprävention und Gesundheitstraining  in Baden-Baden, Karlsruhe, Pfalz, Offenburg, Kehl, Ortenau, Freiburg, Breisgau, Pforzheim, Heidelberg, Ludwigshafen, Mannheim, Stuttgart   (überregional auf Anfrage)
 

JÖRG LINDER AKTIV-TRAINING
Mauerbergstraße 110
76534 Baden-Baden
Tel.: 07223 / 8004699
Mobil: 0177 / 4977232
Mail: info@aktiv-training.de
Fax: 07223 / 8005271
AKTIV-TRAINING:  www.aktiv-training.de
Personal Training: www.personaltrainingbadenbaden.wordpress.com 
Training der Mobilität: http://mobility-walking.blogspot.com